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Xetril Pediatric Drops contains Clonazepam
Xetril Pediatric Drops uses for
Clonazepam (Oral) is indicated in:
Tablet:
• Anxiety disorders (Generalized, Phobic & Panic disorders)
• Insomnia and sleep disturbances
• Labile arterial hypertension
• Peri and Post menopausal anxiety (Anxiety in middle aged women)
• Burning Mouth Syndrome
• Peri and Post menopausal anxiety (Anxiety in middle aged women)
• Postoperative anxiety disorder
• Post traumatic stress disorder
• Anxiety in cancer patient (palliative treatment)
• Tension Headache
• Restless legs syndrome (RLS) or Wittmaack–Ekbom syndrome
• Nocturnal myoclonus
• Tourette's syndrome
• Bipolar affective disorder
• Resistant depression
• Drug-induced dyskinesia
• Choreiform movement
• Fulgurant pain
• Trigeminal neuralgia
• Epilespsy
Injection:
• Epilepsy
• Status epilepticus
• Myoclonic seizure
• Typical and atypical absences (Lennox-Gastaut syndrome)
• Infantile spasm
• Tonic-clonic seizure
• Partial seizure
• Absence seizure
• Focal seizure
Tablet:
Infants and children
Initial dose: 0.01 - 0.03 mg/kg/day. Up to 1 year: 0.25 mg daily in divided dose, not to exceed 0.05 mg/kg/days increase gradually to 0.5 - 1 mg.
Increment dose: not more than 0.25 - 0.5 mg 1 - 5 years: 0.25 mg daily in divided dose, at intervals of 3 days increase to 1 - 3 mg.
Maintenance dose: 0.1 - 0.2 mg/kg/day. 5 - 12 years: 0.5 mg daily in divided dose,
Dosing interval: b.i.d. / t.i.d. increase to 3 - 6 mg.
Adults and elderly
Initial dose: 1 mg daily in divided dose (Elderly 0.5 mg), not to exceed 1.5 mg/day
Increment dose: 0.5 - 1 mg at intervals of 3 days
Maintenance dose: 4 - 8 mg/day
Maximum dose: 20 mg/day should be administered with caution
Dosing interval: b.i.d. / t.i.d.
Initial dose should be low and increased gradually to a maintenance dose that controls seizure without toxic effects. During discontinuation, the dose should be tapered.
Injection:
Infants and children: half of a vial (0.5 mg) by slow IV injection or by IV infusion. Adults: 1 vial (1 mg) by slow IV injection or by IV infusion. This dose can be repeated as required (1 - 4 mg are usually sufficient to reverse the status). In adults, the rate of injection must not exceed 0.25 - 0.5 mg per minute (0.5 – 1.0 mL of the prepared solution) and a total dose of 10 mg should not be exceeded.
Slow intravenous injection: The contents of the vial must be diluted with 1 mL of water for injection prior to administration so as to avoid local irritation of the veins. The injection solution should be prepared immediately before use. IV injection should be administered slowly with continuous monitoring of EEG, respiration and blood pressure.
Intravenous infusion: Clonazepam (the vial) can be diluted for infusion in a ratio of 1 vial (1 mg) to at least 85 mL diluting media. The diluting media can be any of the following: sodium chloride 0.9%; sodium chloride 0.45% + glucose 2.5%; glucose 5% or glucose 10%. These mixtures are stable for 24 hours at room temperature. Infusion bags other than PVC should be used for infusing Clonazepam. If PVC infusion bags are used then the mixture should be infused immediately or within 4 hours. The infusion time should not exceed 8 hours. Do not prepare Clonazepam infusions using sodium bicarbonate solution, as precipitation of the solution may occur.
Intramuscular injection: The IM route should be used only in exceptional cases or if IV administration is not feasible.
Tablet:
Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.
Injection:
Symptoms of Clonazepam overdosage, like those produced by other CNS depressants, include: somnolence, confusion, coma and diminished reflexes.
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