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Phylopen Forte Oral Suspension contains Flucloxacillin Sodium
Phylopen Forte Oral Suspension uses for
Flucloxacillin is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by β-lactamase producing staphylococci.
Skin and Soft Tissue Infections: Boils, abscesses, carbuncles, furunculosis,infected wounds, infected burns, protection of skin grafts, otitis media and externa, impetigo.
Infected Skin Conditions: Ulcer, eczema and acne.
Respiratory Tract Infections: Pneumonia, lung abscess, empyema, sinusitis,pharyngitis, tonsillitis, quinsy.
Other infections caused by Flucloxacillin-sensitive organisms such as osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia.
Flucloxacillin is also indicated for use as a prophylactic agent during major surgical procedures where appropriate, for example, cardiothoracic and orthopaedic surgery
Oral administration:
Adult or Elderly:
- Usual dosage: 250 mg four times daily. In severe infections, dosage should be doubled.
- In osteomyelitis and endocarditis: up to 8 gm daily, in divided doses 6 to 8 hourly.
- In case of secondary bacterial infection in chicken pox: Flucloxacillin 500 mg six hourly should be prescribed.
Children:
- Usual dosage: 20 years: half of the adult dose. Under 2 years: quarter of the adult dose.
Parenteral administration:
Adult or Elderly:
- Intramuscular: 250 mg four times daily.
- Intravenous: 250 mg g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
- All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.
Children:
- Usual dosage: 20 years : half of the adult dose. Under 2 years : quarter of the adult dose.
Doses should be administered half an hour before meals.
Flucloxacillin has been used in other routes in conjunction with systemic therapy. It has been administered in a dose of 250 mg to 500 mg daily by intraarticular injection, dissolved if necessary in a 0.5% solution of lignocaine hydrochloride, and by intrapleural injection in a dose of 250 mg daily. Using powder for injection, 125 mg50 mg has been dissolved in 3 ml of sterile water and inhaled by nebuliser four times daily.
Symptoms: Neurotoxicity (e.g. convulsions, encephalopathy), GI effects (e.g. nausea, vomiting, diarrhoea), blood disorders (e.g. neutropenia, haemolytic anaemia, prolongation of bleeding time, defective platelet function), electrolyte disturbances.
Management: Symptomatic treatment.
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