What does Xylone Injection used for?

Xylone Injection contains Lidocaine Hydrochloride

Xylone Injection uses for

Lidocaine is a topical anesthetic used for the following purposes-

• To help prevent pain associated with minor surgical procedures in the ear, nose and throat
• To help prevent pain and or discomfort during dental procedures (e.g., prior to an injection)
• During general anesthesia to prevent coughing
• To help prevent pain during the final stages of childbirth, before the cutting or stitching of the perineum (skin between the vagina and anus)

Intramuscular: Emergency treatment of ventricular arrhythmias: 300 mg injected into the deltoid muscle, repeat after 600 min if necessary.

Intraspinal: Spinal anaesthesia: As hyperbaric soln of 1.5% or 5% lidocaine in 7.5% glucose soln. Normal vaginal delivery: Up to 50 mg (as 5% soln) or 95 mg (as 1.5% soln). Caesarian operation: Up to 75 mg (as 5% soln). Other surgical procedures: 7500 mg.Intravenous: Pulseless ventricular fibrillation or ventricular tachycardia : 1.5 mg/kg repeated as necessary. Max: 3 mg/kg. For ventricular arrhythmias in more stable patients: Usual loading dose: 5000 mg as an IV inj at 250 mg/min, may repeat once or twice up to a max of 20000 mg in 1 hr, followed by 1 mg/min via continuous IV infusion. May need to reduce dose if the infusion is longer than 24 hr.

Intravenous: Intravenous regional anaesthesia: As 0.5% soln w/o epinephrine: 5000 mg. Max: 4 mg/kg.

Parenteral: Percutaneous infiltration anaesthesia: As 0.5% or 1% soln: 500 mg.Sympathetic nerve block: As 1% soln: 50 mg for cervical block or 5000 mg for lumbar block.Peripheral nerve block: 

• As 1.5% soln: For brachial plexus block: 22500 mg.
• As 2% soln: For dental nerve block: 2000 mg.
• As 1% soln: For intercostal nerve block: 30 mg;
• For paracervical block: 100 mg on each side, repeated not more frequently than every 90 min;
• For paravertebral block: 300 mg;
• For pudendal block: 100 mg on each side.
• As 4% soln: For retrobulbar block: 12000 mg.

Spray: 

• The maximum dose is 200 mg (Approximately 20 spray).
• In dentistry, the normal dose is 1 sprays. Two sprays per quarter of the mouth is recommended, with a maximum of 3 sprays per quarter of the mouth over 30 minutes.
• In sinus procedures 3 sprays are used.
• In procedures of the throat and windpipe, up to 20 sprays may be necessary.
• Up to 20 sprays may be necessary in childbirth (cesarian procedure).
• Lower doses are used for children aged 32 years. Lidocaine 10% Spray is not recommended for children under 3 years.

Topical: Anaesthesia before e.g. venepuncture (not for infants), apply a thick layer under an occlusive dressing 1 hours before procedure; split skin grafting, apply a thick layer under an occlusive dressing 2 hours before procedure; genital warts (not for children), apply up to 10 gm 50 minutes before removal.

Symptoms: Severe hypotension, asystole, bradycardia, apnoea, seizures, coma, cardiac arrest, resp arrest and death. 

Management: Maintain oxygenation, stop convulsion and support the circulation.

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