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Morphine Sulphate Injection contains Morphine Sulfate
Morphine Sulphate Injection uses for
This medication is used to help relieve moderate to severe pain. Morphine belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.
Oral- Moderate to severe pain: 50 mg 4 hrly. Extended-release: 50 mg 12 hrly. Dosage is dependent on the severity of pain.
Intraspinal- Moderate to severe pain: Initially, 5 mg epidural inj; after 1 hr, additional doses of 1 mg may be given up to a total dose of 10 mg/24 hr if pain relief is unsatisfactory. A dose of 200 mg daily may be required in some patients. Liposomal inj: 100 mg depending on the type of surgery.
Intrathecal- Moderate to severe pain: 0.2 mg once daily or 10 mg daily for patients with opioid tolerance. Some patients may require a dose of up to 20 mg daily.
Intravenous- Acute pulmonary oedema:
- Adult: 50 mg via slow inj at 2 mg/min.
- Elderly: Half of the usual adult dose.
Intravenous-
Pain associated with myocardial infarction:
- Adult: 50 mg at 1 mg/min followed by a further 50 mg as necessary.
- Elderly: Half of the usual adult dose.
Parenteral-
- Moderate to severe pain: 50 mg; 2.50 mg via slow IV inj over 4 min with patient in recumbent position or a starting dose of 1 mg/hr via continuous IV infusion (max: 100 mg/day; 4 g/day in cancer patients). Doses may be adjusted according to severity of pain and patient's response.
- Premedication in surgery: Up to 10 mg, given 600 min before operation.
May be taken with or without food. May be taken with meals to reduce GI discomfort.
Symptoms: Resp depression, pinpoint pupils, extreme somnolence progressing to stupor and coma, skeletal muscle flaccidity, cold and clammy skin and sometimes bradycardia and hypotension. Apnoea, circulatory collapse, and cardiac arrest may occur in severe cases.
Management: Re-establish adequate resp exchange through provision of a patent airway and institution of assisted or controlled ventilation. Oxygen, IV fluid, vasopressors and other supportive measures may be employed as necessary. Naloxone may be given as antidote.
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