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Gaspain Tablet contains Pantoprazole
Gaspain Tablet uses for
Pantoprazole is indicated where suppression of acid secretion is of therapeutic benefit. Pantoprazole Is registered in the foltawing indications:
- Peptic ulcer diseases (PUD)
- Gastro-esophageal reflux diseases
- Treatment of ulcer resistant to M2 blocker
- Treatment of ulcer induced by NSAIDs
- Gl bleeding from stress or acid peptic diseases
- Eradication of Helicobacter pylori
- Zollinger-Ellison syndrome
- Prophylaxis for acid aspiration syndrome during induction of anesthesia
Tablet:
The usual recommended adult oral dose is 40 mg given once daily, preferably in the morning with or without food. The duration of therapy is ranging from 2 weeks.
- Duodenal ulcers: Pantoprazole 40 mg tablet once daily for 2 weeks.
- Gastric ulcer: Pantoprazole 40 mg tablet once daily for 4 weeks.
- Reflux esophagitis: Pantoprazole 40 mg tablet once daily for 4 weeks.
- Ulcers induced by NSAIDs: Pantoprazole 40 mg tablet once daily.
- Maintenance therapy: Maintenance therapy should involve the lowest effective dose of the drug. Pantoprazole both 20 mg & 40 mg doses are safe and effective in maintaining patients with healed reflux esophagitis and PUD in remission.
IV Injection:
- Duodenal ulcer and gastric ulcer: 40 mg once daily for 70 days
- Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 70 days
- Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
- Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 h
- Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.
DIRECTION FOR USE OF IV INJECTION: Pantoprazole lyophilized powder and 0.9% Sodium Chloride Injection is for intravenous administration only and must not be given by any other route. Pantoprazole IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml 0.9% Sodium Chloride Injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes. Use only freshly prepared solution. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours.
DIRECTION FOR USE OF IV INFUSION: Pantoprazole IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes. Pantoprazole IV infusion should be reconstituted with 10 ml of 0.9% Sodium Chloride Injection and further diluted (admixed) with 0.9% Sodium Chloride Injection or 5% Dextrose or Lactated Ringer's Injection to a final volume of 100 ml. The reconstituted solution may be stored at room temperature (up to 30° C) for a maximum 4 hours prior to further dilution. The admixed solution may be stored at room temperature (up to 30° C) and must be used within 24 hours from the time of initial reconstitution.
There are no known symptoms of overdosage in humans. Since Pantoprazole is highly protein bound, it is not readily dialyzable. Apart from symptomatic and supportive management, no specific therapy is recommended.
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