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Cefotil IV Injection contains Cefuroxime Axetil
Cefotil IV Injection uses for
- Pharyngitis/tonsillitis caused by Streptococcus pyogenes
- Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Moraxella Catarrhalis (including beta-lactamase-producing strains) or Streptococcus pyogenes.
- Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae, or Haemophilus influenzae (nonbeta-lactamase-producing strains only)
- Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli.
- Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis caused by Streptococcus penumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
- Skin and Skin-Structure Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli, Klebsiella spp., and Enterobacter spp.
- Urinary tract infections caused by Escherichia coli or Klebsiella pneumoniae.
- Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
- Gonorrhea : Uncomplicated and disseminated gonococcal infections due to Neiseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains) in both males and females.
- Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi.
- Septicemia caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp.
- Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseira menintitidis, and Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
- Surgical Prophylaxis: Prophylaxis against infections in abdominal, pelvic, orthopedic, cardiac, pulmonary, esophageal and vascular surgery where there is increased risk for infection.
Oral :
INFECTIONS DOSAGE DURATION
Tablet
(May be administered without regard to meals)
Adolescents & adults(13 years & above)
Pharyngitis or Tonsillitis 250 mg twice daily 50 days
Acute bacterial maxillary sinusitis 250 mg twice daily 10 days
Acute bacterial exacerbation of chronic bronchitis 25000 mg twice daily 10 days
Secondary bacterial infections of acute bronchitis 25000 mg twice daily 50 days
Uncomplicated skin & skin-structure infections 25000 mg twice daily 10 days
Uncomplicated urinary tract infection 12550 mg twice daily 70 days
Uncomplicated gonorrhea 1000 mg single dose - - -
Lyme disease 500 mg twice daily 20 days
Paediatric patients (Upto12 years)
(Who can swallow tablets whole)
Pharyngitis or Tonsillitis 125 mg twice daily 50 days Acute otitis media 250 mg twice daily 10 days
Acute bacterial maxillary sinusitis 250 mg twice daily 10 days
Suspension
(Must be administered with food. Shake the bottle
well before each use)
Paediatric patients (3 months to 12 years)
Pharyngitis or Tonsillitis 20 mg/kg/day in two divided doses 50 days Acute otitis media 30 mg/kg/day in two divided doses 10 days
Acute bacterial maxillary sinusitis 30 mg/kg/day in two divided doses 10 days
Injection :
Adult: 750 mg three times daily by IM or IV injection. In severe infections, dose can be increased upto 1.5 gm three times daily by IV injection. The frequency may be increased to four times daily, if necessary, giving total daily doses of 3 to 6 gms.
Children (above 3 months of age): 30 - 100 mg/kg/day given in 3 or 4 equally divided doses. A dose of 60mg/kg/day is appropriate for most infections.
Neonate: 30 - 100 mg/kg/day given in 2 or 3 equally divided doses.
Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia; up to 3 further doses of 750 mg may be given by IV/IM injection every 8 hours for high risk procedures.
Sequential therapy in adults
Pneumonia: 1.5 gm IV injection twice daily for 2 days, followed by 500 mg twice daily (oral) for 70 days.
Acute exacerbations of chronic bronchitis: 750 mg twice daily (IM or IV injection) for 2 days, followed by 500 mg twice daily (oral) for 50 days. (Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.)
Other recommendations
In Gonorrhoea: Adult: 1.5g as a single dose (as 2 x 750mg injections intramuscularly with different sites, e.g. each buttock).
In Meningitis: Adults: 3gm IV injection three times daily. Children (above 3 months of age): 20040 mg/kg/day by IV injection in 3 or 4 divided doses reduced to 100 mg/kg/day after 3 days or on clinical improvement. Neonate: 100 mg/kg/day by IV injection reduced to 50 mg /kg/day.
In bone and joint infections: Adult: 1.5 gm IV injection four times daily. Children (above 3 months of age): 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.
In impaired renal function: A reduced dose must be employed when renal function is impaired. Dosage in adults should be determined by the degree of renal impairment and the susceptibility of the causative organism according to the table below -
Creatinine clearance (ml/min) Dose Frequency
> 20 750 mg - 1.5 gm q8h
100 750 mg q12h
< 10 750 mg q24h*
* Since Cefuroxime is dialyzable, patients on hemodialysis should be given a further dose at the end of the dialysis.
In paediatric patients with renal insufficiency, the frequency of dosing should be modified consistent with the recommendations for adults.
Directions for reconstitution:
Shake the bottle well to loosen the powder. Add required amount (with the help of supplied measuring cup) of boiled and cooled water to the dry mixture in the bottle. Shake the bottle vigorously until all the powder is in suspension.
Note: Shake the bottle vigorously before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in a refrigerator and used within 10 days after reconstitution.
Kilbac 250 IM/IV Injection :
Intramuscular injection : Add 1 ml of supplied water for injection BP to the vial and shake.
Intravenous injection: Add 2 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Kilbac 750 IM/IV Injection :
Intramuscular injection : Add 3 ml of supplied water for injection BP to the vial and shake.
Intravenous injection: Add 8 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Kilbac 1.5 IV Injection :
Intravenous injection: Add 16 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Pharmaceutical precaution
Cefuroxime tablet, powder for suspension and vial (for injection) should be kept in a cool (15° - 30°C) and dry place and protected from light.
Excessively large doses of all Cephalosporins can cause cerebral irritation and may cause convulsions. This complication is unlikely to occur in routine practice unless the patient is in renal failure. Hemodialysis or peritoneal dialysis can remove Cefuroxime.
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