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Receca 30 GFS Granules for Suspension contains Racecadotril
Receca 30 GFS Granules for Suspension uses for
Racecadotril is indicated for the symptomatic treatment of acute diarrhea.
Racecadotril is a pure intestinal antisecretory active substance. It decreases the intestinal hypersecretion of water and electrolytes induced by cholera toxin or inflammation and does not have effects on basal secretory activity.
Following oral administration, Racecadotril is rapidly absorbed and then hydrolysed to thiorphan, which is an inhibitor of enkephalinase, a cell membrane peptidase located in various tissues, notably the epithelium of the small intestine. This enzyme contributes both to the hydrolysis of exogenous peptides and to the breakdown of endogenous peptides such as enkephalins. Racecadotril protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing hypersecretion. Racecadotril exerts rapid antidiarrhoeal action, without modifying the duration of intestinal transit.
Adults: One capsule initially, regardless of the time of day. Then one capsule three times daily preferably before the main meals.
Children (from 3 months of age): Racecadotril granules should be administered together with oral rehydration. The recommended dose is determined according to body weight: 1.5 mg/kg per administration, three times daily.
- Infants less than 9 kg: one 10 mg sachet 3 times daily.
- Infants from 9 kg to 13 kg: two 10 mg sachets 3 times daily.
- Children from 13 kg to 27 kg: one 30mg sachet 3 times daily.
- Children of more than 27 kg: two 30mg sachets 3 times daily.
No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.
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