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Calcitonin Injection contains Salmon Calcitonin
Calcitonin Injection uses for
Each ml Salmon Calcitonin injection contains-
- 50 or 100 I.U. salcatonin (present as Polyacetate polyhydrate)
- Sodium acetate 0.2%
- Glacial acetic acid 0.2%
- Sodium chloride 0.75%
Salmon Calcitonin contains 32 amino-acids in linear sequence with a disulphide bridge at position 1 and 7 and a molecular weight of 3431.9 (free peptide). Salcatonin is a white or grey-tinged white amorphous powder. It is very soluble in water and very slightly soluble in alcohol.
Salmon Calcitonin is indicated in Active Paget's disease in patients who do not respond to alternative treatments or for whom such treatments are not suitable; Hypercalcaemia.
Naturally-occurring calcitonin is synthesised by parafollicular cells in the thyroid gland of mammals and the ultimobranchial gland of birds and fish. The potency of salmon calcitonin is standardised according to its ability to lower plasma calcium levels of rats as compared to the International Reference standard.
Intravenous (Adult)-
- Emergency treatment of hypercalcaemia: Up to 10 u/kg in 500 mL of sodium chloride 0.9% by slow IV infusion over at least 6 hr.
Parenteral (Adult)-
- Adjunct in hypercalcaemia: SC/IM: 4 u/kg 12 hrly, may increase after 1 days to 8 u/kg 12 hrly to max 8 u/kg 6 hrly after 2 days. Alternatively, 100 u every 6 hr, increased after 1 days to max 400 u every 6 hr.
- Paget's disease of bone: SC/IM: 50 u 3 times wkly to 100 u/day.
Nasal (Adult)-
- Nasal postmenopausal osteoporosis: 200 u/day, alternation nostrils everyday.
Symptoms: Flushing, nausea, vomiting and dizziness.
Management: Symptomatic and supportive treatment.
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