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Trypsin and chymotrypsin in stool that you discovered

Trypsin and Chymotrypsin - An Overview

Trypsin and chymotrypsin are digestive enzymes which are found in the small intestine lining. They work together to break down large protein molecules into smaller peptides and amino acids before they are absorbed into the bloodstream. Trypsin and chymotrypsin are produced by the pancreas as part of the digestive process of the body.

Preparation for Trypsin and Chymotrypsin Test

A trypsin and chymotrypsin test is usually requested by doctors when diagnosing gastrointestinal and digestive disorders. In order to perform this test, the patient is required to fast for 8 to 12 hours ahead of the test. After the specified time has elapsed, the patient will then be given a laxative to force a bowel movement from which the stool sample will be collected and examined.

Procedure for Trypsin and Chymotrypsin Test

The test begins with the collection of a stool sample. The sample will then be tested in a lab for the level of trypsin and chymotrypsin present. The test usually requires the use of a special, chemical specific, enzyme linked immunosorbent assay. After the test is complete, the results will indicate the amount of both trypsin and chymotrypsin present in the sample.

Types of Trypsin and Chymotrypsin Test

The types of trypsin and chymotrypsin tests include a fecal elastase test, a stool pancreatic polypeptide test, a selective trypsinogen test, and a chymotrypsin test.

  • The fecal elastase test measures the amount of elastase present in the stool. This is a protein enzyme which is produced by the pancreas and is used to break down insoluble proteins in the small intestine.
  • The stool pancreatic polypeptide test measures the amount of the protein polypeptide present in the sample. This polypeptide helps to control the release of trypsin and chymotrypsin from the pancreas.
  • The selective trypsinogen test is used to measure the amount of trypsinogen present in the sample. This is an inactive form of the enzyme trypsin which assists in the digestion of proteins.
  • The chymotrypsin test is used to measure the amount of the enzyme chymotrypsin present in the sample. Chymotrypsin assists in digestion by breaking down complex proteins.

Risks Associated with Trypsin and Chymotrypsin Test

There are minimal risks associated with a trypsin and chymotrypsin test. Some people may experience nausea, vomiting, bloating, cramping, or diarrhea as a result of the laxative used to collect the stool sample.

Why is Trypsin and Chymotrypsin Test Important?

A trypsin and chymotrypsin test helps to identify certain digestive disorders such as pancreatitis or cystic fibrosis. Low levels of trypsin and chymotrypsin often indicate a decrease in pancreatic enzyme production which can be a sign of serious underlying issues such as pancreatic cancer. High levels of these enzymes can also indicate inflammation of the pancreas.

When is a Trypsin and Chymotrypsin Test Used?

A trypsin and chymotrypsin test may be requested by doctors when diagnosing gastrointestinal and digestive disorders such as irritable bowel syndrome, malabsorption syndromes, celiac disease, and pancreatic cancer. The test can also be used to monitor the severity of existing gastrointestinal conditions or to determine the effectiveness of treatment for chronic pancreatitis.

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