Secretin stimulation test
What is Secretin Stimulation Test?
Secretin stimulation test is a type of diagnostic test conducted to examine the working of the stomach, bowels, pancreas and gallbladder. In this test, a hormone known as secretin is injected into the body and blood samples are taken at different intervals to measure levels of different substances present in the bloodstream.
Why is Secretin Stimulation Test Conducted?
Secretin stimulation test is done to diagnose abnormal levels of bile, digestive enzymes, and other substances in the bloodstream, which can indicate the presence of pancreatic and bowel diseases. This test is used to diagnose conditions such as cystic fibrosis, gastroenteritis, pancreatitis, and other digestive disorders.
Preparation for Secretin Stimulation Test
Before the procedure, your doctor will ask you about any medications you are currently taking. You may be asked to stop taking certain drugs, such as laxatives, antacids, or painkillers. Your doctor may also advise you to fast for 8–12 hours before the test. You will be asked to drink plenty of fluids during this period.
Types of Secretin Stimulation Test
The basic types of an secretin stimulation test include both intravenous and intraduodenal test. The intravenous type is used to measure levels of gastrin, pancreatic enzymes and bile salts in the blood.
- Intravenous Secretin Stimulation Test – Also known as the Secretin-CGRP test, it examines the secretion of cholecystokinin (CGRP) and gastrin in response to secretin injection.
- Intraduodenal Secretin Stimulation Test – Also known as the Duodenal Motility Test (DMT), this test is used to measure the motility and function of the small intestine.
Procedure of Secretin Stimulation Test
The procedure usually takes 1 to 2 hours. During the test, the patient is asked to lie on a couch while a tube or needle is injected into a vein on the arm. Then, a specialist injects secretin into the bloodstream and collects blood samples at regular intervals. The samples are then tested for levels of several substances, such as gastrin, bile, pancreatic enzymes, and bicarbonates.
Risks Involved in Secretin Stimulation Test
The secretin stimulation test is generally a safe procedure with no notable side effects and very low risks of complications. In rare cases, the test may cause discomfort, nervousness, anxiety, and nausea. Your doctor may advise you to avoid certain activities post the procedure, such as eating or drinking for a certain amount of time.
When is the Secretin Stimulation Test Recommended?
The secretin stimulation test is usually recommended when other tests fail to detect pancreatic and bowel diseases. It is also used to diagnose conditions such as cystic fibrosis, gastroenteritis, pancreatitis, and other digestive disorders.
