PBG urine test
What is a PBG Urine Test?
A PBG urine test (Phenylalanine-b-glucuronide urine test) is used to measure the presence of the amino acid phenylalanine (Phe) in urine. Phenylalanine is a component of certain proteins found in the body and is essential for normal growth and development.
Why is a PBG Urine Test done?
A PBG urine test is usually done to diagnose inherited metabolic disorders such as phenylketonuria (PKU) and homocystinuria. PKU is a genetic disorder in which the body cannot break down phenylalanine properly. Homocystinuria is an inherited disorder that can cause the body to metabolize methionine, an amino acid, improperly.
When is a PBG Urine Test done?
A PBG urine test is often part of a routine newborn screening test. It is also used to monitor the levels of phenylalanine in the body in patients with existing metabolic disorders. Other tests may be ordered to confirm the diagnosis.
Preparation for a PBG Urine Test
No special preparation is needed before the test. However, if the patient has been eating foods or taking certain medications that contain phenylalanine, it is important to inform the doctor in advance.
Procedure for a PBG Urine Test
For the test, a urine sample is collected and analyzed in the laboratory. The laboratory test will measure the amounts of phenylalanine and its breakdown product phenylalanine-b-glucuronide (PBG). Abnormal levels of PBG in the urine indicate a metabolic disorder. The results of the test will help the doctor determine the diagnosis and recommend the appropriate treatment.
Types of PBG Urine Tests
There are two types of PBG urine tests: qualitative and quantitative. The qualitative test determines whether there are any elevated levels of PBG in the urine. The quantitative test measures the exact levels of PBG in the urine. This test can provide more detailed information about the patient's condition.
Risks of a PBG Urine Test
There are no risks associated with this test if it is performed correctly. However, if the results of the test are misinterpreted, it can lead to unnecessary treatment or the patient not getting the proper treatment they need.
