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C1 esterase inhibitor .

What is C1 esterase inhibitor?

C1 esterase inhibitor (C1-INH) is a protein produced in the liver that helps regulate certain bodily functions during an allergic reaction, including inflammation.

It helps to prevent certain allergic reactions and inflammation in the body by breaking down the substances that cause an inflammatory response. C1-INH is produced by the liver and is released into the blood stream.

Types of C1-INH

C1-INH can be found in different forms, including:

  • Human C1-INH: This type is made from human plasma.
  • Recombinant C1-INH: This type is artificially produced using genetic engineering.
  • Porcine C1-INH: This type is made from pig plasma.

Preparation of C1-INH

C1-INH can be prepared in several different ways. It can be made synthetically in a laboratory setting or it can be derived from animal sources. Synthetic C1-INH is typically used in medical settings, while animal-derived C1-INH is used as a dietary supplement.

The type of C1-INH used depends on the patient's needs. For example, a patient who is allergic to porcine products may receive recombinant C1-INH, while a patient with a condition that affects their immune system may receive human C1-INH.

Uses of C1-INH

C1-INH is used to treat a variety of different conditions, including:

  • Hereditary angioedema: a genetic condition that causes recurrent episodes of swelling of the face, throat, and extremities.
  • Acute liver failure: C1-INH is used to help reduce inflammation in the liver and prevent further damage.
  • Inflammatory bowel disease: C1-INH is used to decrease inflammation in the gut.
  • Asthma: C1-INH is used to help reduce inflammation in the airways and improve breathing.
  • Rheumatoid arthritis: C1-INH is used to reduce inflammation in the joints.

Risks of C1-INH

C1-INH carries a risk of allergic reactions and other side effects. These can include:

  • Itching
  • Hives
  • Fainting
  • Wheezing
  • Fever
  • Rashes
  • Difficulty breathing
  • Low blood pressure
  • Nausea
  • Diarrhea
  • Headaches

These side effects are typically mild and go away on their own. If you experience any of these symptoms after taking C1-INH, seek medical help immediately.

Why and When to take C1-INH?

C1-INH is typically prescribed to treat an underlying condition that causes inflammation or an allergic reaction. It can be used to reduce the severity of the symptoms or to prevent a reaction from occurring.

You may also be prescribed C1-INH if you’re at risk of experiencing a severe allergic reaction known as anaphylaxis. This type of reaction can be life-threatening and requires immediate medical attention.

Your doctor will decide if C1-INH is the appropriate treatment for you, based on your particular condition or allergy.

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