TP53 Genetic Test

What is a TP53 Genetic Test?

TP53 genetic tests assess a patient’s DNA for the presence of mutations in the TP53 gene. TP53-related gene mutations are most commonly associated with a variety of cancers, including lung, breast, colorectal, and ovarian cancers.

Why is a TP53 Genetic Test Used?

A TP53 genetic test is used to detect a mutation in the TP53 gene, which could be associated with cancer. The TP53 gene is responsible for the production of a protein that helps control the number of cells in the body, as well as how the cells grow and develop. Mutations in the TP53 gene, can cause the out-of-control production of cancerous cells. These mutations are linked to several different types of cancers, making a TP53 genetic test an important component of cancer diagnosis.

When is a TP53 Genetic Test Used?

A TP53 genetic test may be recommended for individuals exhibiting symptoms suggestive of cancer, particularly those of a certain types. It can also be used for individuals with a family history of cancer who may be at higher risk for carrying a TP53 mutation. Depending on the individual, a TP53 genetic test may be recommended alongside other tests that may help them narrower the scope of condition.

Types of TP53 Genetic Tests

There are two types of TP53 genetic tests:

• Full gene sequencing- This test looks at all of the genes in the TP53 gene to identify any mutations.
• Mutation-specific testing-This test looks for specific known mutations in the TP53 gene.

How is a TP53 Genetic Test Performed?

In order to perform a TP53 genetic test, a sample of cells, typically collected through a blood or saliva sample, is needed. The sample is then sent to a lab, where the TP53 gene is analyzed for any mutations. Depending on the test being performed, a full analysis of the gene may be done or the lab may be looking for specific known mutations in the TP53 gene.

Risks of a TP53 Genetic Test

As with any test, there is a risk of discomfort or pain associated with the collection of the samples. In some cases, there may also be a risk of an allergic reaction to any medications or solutions used in the sample collection process. However, the risks associated with a TP53 genetic test are minimal and any discomfort or pain can usually be managed with medication or a cooling device.