Methylmalonic Acid (MMA) Test

What Is Methylmalonic Acid (MMA) Test?

Methylmalonic Acid (MMA) Test is a type of laboratory test used to measure the levels of methylmalonic acid in the blood. This test is used to detect metabolic disorders caused by vitamin B12 or folate deficiencies.

Why Is the Methylmalonic Acid (MMA) Test Done?

MMA test is done to:

• Detect and diagnose Vitamin B12 and folate deficiency anemia
• Evaluate the functioning of the kidneys
• Check for vitamin B12 and folate absorption, as well as metabolism problems
• Diagnose diseases such as Addison’s disease, liver disease, and celiac disease

Preparation for Methylmalonic Acid (MMA) Test

No special preparation is needed for the Methylmalonic Acid test. All that is required is to inform your doctor about any medications you are taking as they may alter the test results.

Procedure for Methylmalonic Acid (MMA) Test

MMA Test is a simple procedure. During the test, a small needle is used to draw the blood sample from the arm of the patient. Blood sample is then sent to the lab where it is tested for MMA levels. The test results are then compared to the reference ranges and analyzed.

Types of Methylmalonic Acid (MMA) Tests

• Serum MMA Test: Serum MMA test is used to measure the amount of methylmalonic acid present in the blood i.e., it is used to determine if the patient is deficient in Vitamin B12 or folate.
• Urinary MMA Test: Urinary MMA test is used to measure the amount of methylmalonic acid excreted in the urine. It is used to diagnose a variety of metabolic disorders such as Addison’s disease, liver disease, celiac disease, and other vitamin deficiencies.

Risks Involved with Methylmalonic Acid (MMA) Test

The risks involved with Methylmalonic acid test are minimal. However, some people may experience pain, bruising, or redness at the injection site due to the needle.

When Is the Methylmalonic Acid (MMA) Test Recommended?

MMA Test is recommended in the following cases:

• If the patient has anemia due to vitamin B12 or folate deficiency
• If the patient has unexplained symptoms
• If the patient has a family history of anemia
• If the patient is taking medications that may interfere with functionality of vitamin B12 and folate
• If the patient is being treated for B12 or folate deficiency