Pituitary-dependent Cushing's syndrome

Pituitary-dependent Cushing's Syndrome

Pituitary-dependent Cushing's disease is a condition which is caused by overproduction of the hormones called cortisol.

It is caused by a tumor forming on the pituitary gland. Most of these tumors are benign noncancerous, however, they can cause serious health consequences such as diabetes, high blood pressure, and osteoporosis. Stimulating these tumors with drugs or radiation can cause them to shrink, but they can also reform even after successful treatment.

Symptoms of pituitary-dependent Cushing's syndrome vary depending on the severity of the symptom. Often, the first symptom is rapid weight gain, usually in the face, neck, upper back, and abdomen. Other symptoms include fatigue, decreased energy, muscle weakness, iHigh blood pressure, rounded face, fragile skin that bruises easily, purple stretch marks, insomnia and depression.

Diagnosing pituitary-dependent Cushing's syndrome involves medical, neurological, and endocrine testing. Common tests used are a physical exam, glucose tolerance test, ACTH stimulation test, adrenocorticotropic hormone (ACTH) suppression test, and computed tomography (CT) or magnetic resonance imaging (MRI).

Treatment for this condition depends on how far the condition has progressed. Surgery may be recommended if the tumor is in a small, operable area. Other treatments may include medications, radiotherapy, or chemotherapy.

Complications of pituitary-dependent Cushing's disease include an increased risk of infection, diabetes, high blood pressure, and osteoporosis. With early diagnosis and proper treatment, these complications may be avoided or minimized.

Living with pituitary-dependent Cushing's disease can be challenging, but there are ways to manage the symptoms and improve your quality of life. Regular exercise and healthy eating can help to control weight gain and keep your energy levels up. Counseling and support groups can also be helpful in managing the emotional strain of the condition.