Prosthetic groups differ from co-enzymes in that –

(A) They can serve as co-factors in a number of enzyme – catalyzed reactions

(B) They require metal ions for their activity

(C) They (prosthetic groups) are tightly bound to apoenzymes

(D) Their association with apoenzymes is transient

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(C) They (prosthetic groups) are tightly bound to apoenzymes

 Apoenzyme (protein part) and co-factor together form a complete catalytically active enzyme which is known as holoenzyme. The co-factors are of two types; metal ions and coenzymes. A coenzyme or metal ion that is very tightly or even covalently bound to the enzyme protein is known as a prosthetic group.

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