Anitaji needs to micturate several times and feels very thirsty. This is an indication of change in permeability of

1. Need to micturate several times (polyuria) and feeling very thirsty (polydipsia) is a symptom of diabetes insipidus (imbalance of fluids in the body). 

2. ADH prevents diuresis and due to absence of ADH, large amount of dilute urine is excreted. 

3. ADH stimulates reabsorption of water from last part of DCT and entire collecting duct by increasing the permeability of cells. 

4. If the permeability of these cells changes, it will result in increase in urine volume (frequent micturition) and increase in the osmolarity of blood. An imbalance in volume and osmolarity of body fluids increases thirst.