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According to the Hebrew Bible, circumcision was enjoined upon the biblical patriarch Abraham, his descendants and their slaves as "a token of the covenant" concluded with him by God for all generations, as an "everlasting covenant".

The Council of Jerusalem during the Apostolic Age of the history of Christianity did not include religious male circumcision as a requirement for new gentile converts. This became known as the "Apostolic Decree": "But to still the clamours of the converts from Pharisaism who demanded that the Gentile converts "must be circumcised and be commanded to observe the Law of Moses", the matter was discussed in a public meeting.... By the decree of the Apostles the cause of Christian liberty was won against the narrow Judaizers, and the way smoothed for the conversion of the nations. The victory was emphasized by St. Paul's refusal to allow Titus to be circumcised even as a pure concession to the extremists." It may be one of the first acts differentiating early Christianity from Judaism.

Circumcision has played an important role in Christian history and theology; the circumcision of Jesus is celebrated as a feast day in the liturgical calendar of many Christian denominations, while Paul's teaching that physical circumcision was unnecessary for membership in the new covenant was instrumental in the separation of Christianity from Judaism. In some Eastern Christian denominations male circumcision is an established practice, and males are generally required to be circumcised shortly after birth as part of a rite of passage. Circumcision is widely practiced in many Christian countries and communities.

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