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Focal neurologic signs also known as focal neurological deficits or focal CNS signs are impairments of nerve, spinal cord, or brain function that affects a specific region of the body, e.g. weakness in the left arm, the right leg, paresis, or plegia.

Focal neurological deficits may be caused by a variety of medical conditions such as head trauma, tumors or stroke; or by various diseases such as meningitis or encephalitis or as a side effect of certain medications such as those used in anesthesia.

Neurological soft signs, are a group of non-focal neurologic signs.

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