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Madonna and Child with Two Saints and a Donor is a c.1395-1400 tempera and gold leaf on panel painting by Gentile da Fabriano, the earliest surviving major work by the artist. Probably painted for the church of Santa Caterina in Castelvecchio in Fabriano , near to which it is now in the Gemäldegalerie in Berlin.
On the right is Catherine of Alexandria, referring to the name of the church for which the work was probably produced. To the left is Nicholas of Bari presenting the work's donor - the latter dressed as a merchant and may be Ambrogio di Bonaventura , whose golden mark is to be seen at his feet.
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