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WAGR syndrome is a rare genetic syndrome in which affected children are predisposed to develop Wilms tumour , Aniridia , Genitourinary anomalies, and mental Retardation. The G is sometimes instead given as "gonadoblastoma," since the genitourinary anomalies can include tumours of the gonads.
Some WAGR syndrome patients show severe childhood obesity and hyperphagia; the acronym WAGRO has been used to describe this category and may be associated with the coinciding loss of BDNF a gene that is also on chromosome 11.
The condition, first described by Miller et al. in 1964 in its association with other congenital malformations, results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring genes.
It is possible for those with WAGR syndrome to develop Wilms tumor, a rare form of kidney cancer.