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The PTS Galactitol Family is part of the PTS-AG superfamily. The biochemistry of this family is poorly defined. The only well-characterized member of this family is the galactitol permease of Escherichia coli. However, a homologous IIC protein from Listeria monocytogenes has been shown to be required for D-arabitol fermentation. It presumably functions together with IIA and IIB homologues. IIC is distantly related to IIC of E. coli; IIA is distantly related to IIA and IIAof E. coli as well as IIA and IIA. IIB is distantly related to IIB and IIB of E. coli. Domains in the LicR/CelR family of transcriptional activators show C-terminal domains exhibiting weak sequence similarity to IIB and IIA.
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