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Perfluoropropionic acid or pentafluoropropionic acid is the perfluoroalkyl carboxylic acid with the formula CF3CF2CO2H. It is a colorless liquid that is strongly acidic and soluble in water and polar organic solvents.

A convenient, safe method for generating tetrafluoroethylene is the pyrolysis of the sodium salt of pentafluoropropionic acid:

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