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In organic chemistry, the Jocic reaction, also called the Jocic–Reeve reaction is a name reaction that generates α-substituted carboxylic acids from trichloromethylcarbinols and corresponding nucleophiles in the presence of sodium hydroxide. The reaction involves nucleophilic displacement of the hydroxyl group in a 1,1,1-trichloro-2-hydroxyalkyl structure with concomitant conversion of the trichloromethyl portion to a carboxylic acid or similar functional group.
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