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In enzymology, a histidine N-acetyltransferase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are acetyl-CoA and L-histidine, whereas its two products are CoA and N-acetyl-L-histidine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:L-histidine N-acetyltransferase. Other names in common use include acetylhistidine synthetase, and histidine acetyltransferase.

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