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In enzymology, an oxalate—CoA ligase is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are ATP, oxalate, and coenzyme A , whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase. Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Organisms with Oxalate-CoA Ligases include:Arabidopsis thalianaSaccharomyces cerevisiae

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