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In enzymology, a methylamine-glutamate N-methyltransferase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are methylamine and l-glutamate, whereas its two products are NH3 and N-methyl-l-glutamate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methylamine:l-glutamate N-methyltransferase. Other names in common use include N-methylglutamate synthase, and methylamine-glutamate methyltransferase. This enzyme participates in methane metabolism.

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