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Permease of phosphotransferase system is a superfamily of phosphotransferase enzymes that facilitate the transport of L-ascorbate and galactitol. Classification has been established through phylogenic analysis and bioinformatics.
The bacterial phosphoenolpyruvate:sugar phosphotransferase system transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I , HPr, Enzyme IIA , and Enzyme IIB ] as well as the integral membrane sugar permease. The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the Glucose , Mannose , Ascorbate-Galactitol and Dihydroxyacetone superfamilies.
The four families that make up the PTS-GFL superfamily include: