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In enzymology, a gamma-glutamylcyclotransferase is an enzyme that catalyzes the chemical reaction

Hence, this enzyme has one substrate, -L-amino acid, and two products, 5-oxoproline and L-amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is -L-amino-acid 5-glutamyltransferase. Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.

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