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In linear algebra, geometry, and trigonometry, the Cayley–Menger determinant is a formula for the content, i.e. the higher-dimensional volume, of a n {\textstyle n} -dimensional simplex in terms of the squares of all of the distances between pairs of its vertices. The determinant is named after Arthur Cayley and Karl Menger.
The {\displaystyle {n \choose 2}} pairwise distance polynomials between n points in a real Euclidean space are Euclidean invariants that are associated via the Cayley-Menger relations. These relations served multiple purposes such as generalising Heron's Formula, computing the content of a n-dimensional simplex, and ultimately determining if any real symmetric matrix is a Euclidean distance matrix in the field of Distance geometry.