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Fringe genes are important in the workings of the notch signaling pathway.
In Drosophila melanogaster the fringe gene was identified as part of the notch mechanism by Dr. Kenneth Irvine at the Waksman Institute at Rutgers. Later based on similarity, the manic fringe , the radical fringe and lunatic fringe genes were identified in mammals.
Fringe genes encode O-fucose specific β-1,3-N-Acetylglucosaminyltransferases glycosyltransferases.
The gene products of radical fringe stimulate the Apical Ectodermal Ridge in limb-bud formation.
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