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In enzymology, ferredoxin hydrogenase , also referred to as hydrogenase, H2 oxidizing hydrogenase, H2 producing hydrogenase, bidirectional hydrogenase, hydrogenase , hydrogenlyase, and uptake hydrogenase, is found in Clostridium pasteurianum, Clostridium acetobutylicum, Chlamydomonas reinhardtii, and other organisms. The systematic name of this enzyme is hydrogen:ferredoxin oxidoreductase
Ferredoxin hydrogenase belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with an iron-sulfur protein as acceptor. Ferredoxin hydrogenase has an active metallocluster site referred to as an "H-cluster" or "H domain" that is involved in the inter-conversion of protons and electrons with hydrogen gas.