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Trifluoromethanesulfonic anhydride, also known as triflic anhydride, is the chemical compound with the formula 2O. It is the acid anhydride derived from triflic acid. This compound is a strong electrophile, useful for introducing the triflyl group, CF3SO2. Abbreviated Tf2O, triflic anhydride is the acid anhydride of the strong acid triflic acid, CF3SO2OH.

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