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The transporter-opsin-G protein-coupled receptor superfamily is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments. It includes ion-translocating microbial rhodopsins and G protein-coupled receptors , Sweet sugar transporters, nicotinamide ribonucleoside uptake permeases , 4-toluene sulfonate uptake permeases ; TC# 2.A.102], Ni–Co transporters ; TC# 2.A.52], organic solute transporters ; TC# 2.A.82], phosphate:Na symporters ; TC# 2.A.58] and lysosomal cystine transporters ; TC# 2.A.43].
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