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In enzymology, a pyrroloquinoline-quinone synthase is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are 6--7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate, and O2, whereas its 3 products are 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrroloquinoline-2,7,9-tricarboxylate, H2O2, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is 6--7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinol ine-2,4-dicarboxylate:oxygen oxidoreductase. This enzyme is also called PqqC.

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