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In human mitochondrial genetics, Haplogroup D is a human mitochondrial DNA haplogroup.It is a descendant haplogroup of haplogroup M, thought to have arisen somewhere in Asia, between roughly 60,000 and 35,000 years ago.

In contemporary populations, it is found especially in Central and Northeast Asia. Haplogroup D is one of five main haplogroups found in the indigenous peoples of the Americas, the others being A, B, C, and X.

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