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In enzymology, a betaine-aldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are betaine aldehyde, NAD, and H2O, whereas its 3 products are betaine, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is betaine-aldehyde:NAD+ oxidoreductase. Other names in common use include betaine aldehyde oxidase, BADH, betaine aldehyde dehydrogenase, and BetB. This enzyme participates in glycine, serine and threonine metabolism.

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