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β-Neoendorphin is an endogenous opioid peptide with a nonapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro.
β-Neoendorphins have the capability to stimulate wound healing by accelerating keratinocyte migration. This is achieved by β-NEP's activation of mitogen-activated protein kinase and extracellular signal-regulated kinases 1 and 2 ; along with the upregulation of matrix metalloproteinase 2 and 9. Wound healing by β-NEP results in migration without consequences on proliferation in human keratinocytes.
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