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The SET domain is a protein domain that typically has methyltransferase activity. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived 3-9, Enhancer-of-zeste and Trithorax].
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