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Activated protein C–protein C inhibitor is a complex of activated protein C and protein C inhibitor. It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications. It is a marker of thrombin generation and indicates hypercoagulability. The half-life of APC-PCI is either 40 minutes or 140 minutes.
Ethinylestradiol-containing birth control pills have been found to increase levels of APC-PCI to a similar degree as thrombin–antithrombin complex and to a greater extent than D-dimer. However, only APC-PCI was able to differentiate between a second- and third-generation birth control pill.
Another complex related to APC-PCI is the activated protein C–α1-antitrypsin complex.
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