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In enzymology, a NADPH peroxidase is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are NADPH, H, and H2O2, whereas its two products are NADP and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor. The systematic name of this enzyme class is NADPH:hydrogen-peroxide oxidoreductase. Other names in common use include TPNH peroxidase, NADP peroxidase, nicotinamide adenine dinucleotide phosphate peroxidase, TPN peroxidase, triphosphopyridine nucleotide peroxidase, and NADPH2 peroxidase.

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