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COS are fibroblast-like cell lines derived from monkey kidney tissue. COS cells are obtained by immortalizing CV-1 cells with a version of the SV40 virus that can produce large T antigen but has a defect in genomic replication. The CV-1 cell line in turn was derived from the kidney of the African green monkey.
The acronym "COS" is derived from the cells being CV-1 in Origin, and carrying the SV40 genetic material. Three COS lines were created , of which two are commonly used.
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