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The parieto-occipital sulcus is a deep sulcus in the cerebral cortex that marks the boundary between the cuneus and precuneus, and also between the parietal and occipital lobes. Only a small part can be seen on the lateral surface of the hemisphere, its chief part being on the medial surface.

The lateral part of the parieto-occipital sulcus is situated about 5 cm in front of the occipital pole of the hemisphere, and measures about 1.25 cm. in length.

The medial part of the parieto-occipital sulcus runs downward and forward as a deep cleft on the medial surface of the hemisphere, and joins the calcarine fissure below and behind the posterior end of the corpus callosum. In most cases, it contains a submerged gyrus.

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