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Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na-nucleoside cotransporter localised to the bile canalicular membrane. SLC28A1 is a Na-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the anti-viral nucleoside analogues Zidovudine and Zalcitabine.
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