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Genome size is the total amount of DNA contained within one copy of a single complete genome. It is typically measured in terms of mass in picograms of a gram, abbreviated pg] or less frequently in daltons, or as the total number of nucleotide base pairs, usually in megabases. One picogram is equal to 978 megabases. In diploid organisms, genome size is often used interchangeably with the term C-value.

An organism's complexity is not directly proportional to its genome size; total DNA content is widely variable between biological taxa. Some single-celled organisms have much more DNA than humans, for reasons that remain unclear.

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