What is Gradient enhanced NMR spectroscopy?

Gradient enhanced NMR is a method for obtaining high resolution nuclear magnetic resonance spectra without the need for phase cycling. Gradient methodology is used extensively for two purposes, either rephasing or dephasing of a particular magnetization transfer pathway. It includes the application of magnetic field gradient pulses to select specific coherences. By using actively shielded gradients, a gradient pulse is applied during the evolution period of the selected coherence to dephase the transverse magnetization and another gradient pulse refocuses the desired coherences remaining during the acquisition period.