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Pouilly-sur-Loire , literally Pouilly on Loire] is a commune in the Nièvre department in central France.

Pouilly-sur-Loire is a town noted for the white wine known as Pouilly-Fumé. There are several domaines that wine-tourists can visit and sample wines. Two of those domaines are actual chateaux. Pouilly-sur-Loire station has rail connections to Nevers and Cosne-sur-Loire.

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