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Protein poisoning is an acute form of malnutrition caused by a diet deficient in fat and carbohydrates, where almost all calories consumed come from the protein in lean meat. The concept is discussed in the context of paleoanthropologial investigations into the diet of ancient humans, especially during the last glacial maximum and at high latitudes.

The term rabbit starvation originates from the fact that rabbit meat is very lean, with almost all of its caloric content from protein rather than fat, and therefore a food which, if consumed exclusively, would cause protein poisoning. Animals in harsh, cold environments similarly become lean.

The reported symptoms include initial nausea and fatigue, followed by diarrhea and ultimately death.

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