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A Coulter counter is an apparatus for counting and sizing particles suspended in electrolytes. The Coulter principle, and the Coulter counter that is based on it, is the commercial term for the technique known as resistive pulse sensing or electrical zone sensing.
A typical Coulter counter has one or more microchannels that separate two chambers containing electrolyte solutions. As fluid-containing particles or cells are drawn through each microchannel, each particle causes a brief change to the electrical resistance of the liquid. The counter detects these changes in electrical resistance.
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