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Crotalidae polyvalent immune fab, sold under the brandname CroFab, is a snake antivenin, indicated for minimal or moderate North American Crotalid snake envenomation.
CroFab is composed of several monovalent Fragment antigen-binding proteins derived from the blood of sheep immunized with one of four snake venom: Crotalus atrox , Crotalus adamanteus , Crotalus scutulatus , or Agkistrodon piscivorus. Each monospecific antivenin is purified from sheep serum, digested with the enzyme papain, and purified further resulting in specific Fab fragments. The resulting four different Fab preparations are mixed to formulate the final product.
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